Not fibrin(ogen), but fibrinogen or fibrin

Blood. 2015 Oct 22;126(17):1977-8. doi: 10.1182/blood-2015-08-662551.


In this issue of Blood, Prasad et al describe a mouse model with a mutation in the Aα chain of fibrinogen such that no fibrin polymer is formed in vivo, allowing for the first time the differentiation of the role of fibrinogen vs fibrin oligomer or polymer in antimicrobial host defense and in hemostasis/thrombosis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Fibrin / metabolism*
  • Fibrinogen / physiology*
  • Host-Pathogen Interactions*
  • Mutation / genetics*
  • Peritonitis / etiology*
  • Staphylococcal Infections / immunology*
  • Staphylococcus aureus / immunology*


  • Fibrin
  • Fibrinogen