Much ado about zero

Jef D Boeke; David Fenyo

doi:10.1016/j.cell.2015.10.033

Much ado about zero

Cell. 2015 Oct 22;163(3):534-5. doi: 10.1016/j.cell.2015.10.033. Epub 2015 Oct 22.

Authors

Jef D Boeke¹, David Fenyo²

Affiliations

¹ Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA. Electronic address: jef.boeke@nyumc.org.
² Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.

PMID: 26496595
DOI: 10.1016/j.cell.2015.10.033

Abstract

LINE retrotransposons actively shape mammalian genomes. Denli et al. reveal a new open reading frame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein. This finding may represent the birth of an emerging retrotransposon gene that can adopt various fates, as it can be fused to adjacent host sequences.

Publication types

Comment

MeSH terms

Animals
Humans
Pan troglodytes / genetics*
Retroelements*

Substances

Retroelements

Grants and funding

P50 GM107632/GM/NIGMS NIH HHS/United States