Much ado about zero

Cell. 2015 Oct 22;163(3):534-5. doi: 10.1016/j.cell.2015.10.033. Epub 2015 Oct 22.


LINE retrotransposons actively shape mammalian genomes. Denli et al. reveal a new open reading frame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein. This finding may represent the birth of an emerging retrotransposon gene that can adopt various fates, as it can be fused to adjacent host sequences.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Pan troglodytes / genetics*
  • Retroelements*


  • Retroelements