Lessons Learned From the ESPN/ERA-EDTA Registry

Pediatr Nephrol. 2016 Nov;31(11):2055-64. doi: 10.1007/s00467-015-3238-8. Epub 2015 Oct 24.

Abstract

End-stage renal disease (ESRD) in children is a medically challenging condition. Due to its rarity and special features, methodologically sound collaborative studies are required. In 2007, a new European registry of pediatric renal replacement therapy (RRT), the ESPN/ERA-EDTA Registry, was launched. In recent years, the Registry has provided comprehensive data on incidence, prevalence, patient characteristics, RRT modalities, and mortality in pediatric ESRD, along with relevant insights into cardiovascular risk, anemia, nutrition and growth, transplantation outcomes, and rare diseases. In this review, we describe the study design and structure underlying the ESPN/ERA-EDTA Registry, summarize the major research findings from more than 20 publications, and discuss current limitations and the future challenges to overcome.

Keywords: Comorbidities; ESPN/ERA–EDTA registry; End-stage renal disease; Outcome; Pediatric patients; Renal replacement therapy.

Publication types

  • Review

MeSH terms

  • Anemia / epidemiology
  • Anemia / etiology
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / etiology
  • Child
  • Europe / epidemiology
  • Humans
  • Incidence
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / epidemiology*
  • Kidney Failure, Chronic / therapy
  • Kidney Transplantation / methods
  • Kidney Transplantation / statistics & numerical data*
  • Prevalence
  • Rare Diseases / epidemiology*
  • Rare Diseases / therapy
  • Registries*
  • Renal Dialysis / methods
  • Renal Dialysis / statistics & numerical data*
  • Risk Factors
  • Treatment Outcome