Printable Ultrathin Metal Oxide Semiconductor-Based Conformal Biosensors

ACS Nano. 2015 Dec 22;9(12):12174-81. doi: 10.1021/acsnano.5b05325. Epub 2015 Oct 29.


Conformal bioelectronics enable wearable, noninvasive, and health-monitoring platforms. We demonstrate a simple and straightforward method for producing thin, sensitive In2O3-based conformal biosensors based on field-effect transistors using facile solution-based processing. One-step coating via aqueous In2O3 solution resulted in ultrathin (3.5 nm), high-density, uniform films over large areas. Conformal In2O3-based biosensors on ultrathin polyimide films displayed good device performance, low mechanical stress, and highly conformal contact determined using polydimethylsiloxane artificial skin having complex curvilinear surfaces or an artificial eye. Immobilized In2O3 field-effect transistors with self-assembled monolayers of NH2-terminated silanes functioned as pH sensors. Functionalization with glucose oxidase enabled d-glucose detection at physiologically relevant levels. The conformal ultrathin field-effect transistor biosensors developed here offer new opportunities for future wearable human technologies.

Keywords: aqueous process; biosensor; conformal; field-effect transistor; flexible; metal oxide semiconductor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Blood Glucose / analysis
  • Humans
  • Indium / chemistry*
  • Pliability
  • Semiconductors*


  • Blood Glucose
  • Indium
  • indium oxide