Controversy: are systemic steroids indicated in the treatment of erythema multiforme?

Pediatr Dermatol. 1989 Mar;6(1):43-50. doi: 10.1111/j.1525-1470.1989.tb00266.x.


The treatment of erythema multiforme major with systemic steroids became established during the 1950s. Recently, two retrospective case reviews comparing steroid-treated and nonsteroid-treated groups of patients with erythema multiforme found that these agents may be associated with complications. As a result, many clinicians have become uncertain as to the appropriate therapy of this disease entity. We successfully treated the condition with steroids in two children and one adolescent. The controversy over the potential efficacy of such therapy for erythema multiforme persists, however.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Erythema Multiforme / drug therapy*
  • Female
  • Humans
  • Infant
  • Male
  • Methylprednisolone / therapeutic use


  • Adrenal Cortex Hormones
  • Methylprednisolone