Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial

Surg Obes Relat Dis. 2016 Jan;12(1):57-61. doi: 10.1016/j.soard.2015.07.010. Epub 2015 Jul 18.


Background: Gastric bypass surgery is the recommended treatment for severely obese patients. However, postoperative symptomatic gastrointestinal (GI) episodes are common complaints.

Objectives: To determine if administration of probiotics improves symptomatic GI episodes after gastric bypass surgery.

Setting: Hospital-based bariatric center.

Methods: This double-blind, randomized trial was conducted between March 2010 and September 2010 with 60 patients who underwent gastric bypass for severe obesity and experienced postoperative symptomatic GI episodes. Patients were randomly assigned to the probiotics group A (n = 20; 1 g Clostridium butyricum MIYAIRI twice daily); probiotics group B (n = 20; Bifidobacterium longum BB536 twice daily); or digestive enzymes group (n = 20; Aczym, containing 100 mg takadiastase N, 20 mg cellulase AP, 50 mg lipase MY, and 100 mg pancreatin, twice daily). Quality of life was measured using the modified Gastrointestinal Quality of Life Index (mGIQLI) before and after the 2-week intervention.

Results: Preintervention patient characteristics and mGIQLI scores were similar among the 3 groups. After the 2-week intervention, the mean mGIQLI score improved from 57.4 to 63.9 points in the entire sample and also within each group for 7 items specifically for 7: excessive passage of gas, foul smell of flatulence, belching, heartburn, abdominal noises, abdominal bloating, and abdominal pain.

Conclusions: Administration of probiotics or digestive enzymes may improve symptomatic GI episodes after gastric bypass surgeries and improve quality of life, at least initially.

Keywords: Gastric bypass; Probiotics; Quality of life.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Gastric Bypass / standards*
  • Humans
  • Male
  • Middle Aged
  • Obesity, Morbid / psychology
  • Obesity, Morbid / surgery*
  • Postoperative Complications / prevention & control*
  • Probiotics / administration & dosage*
  • Prospective Studies
  • Quality Indicators, Health Care*
  • Quality of Life*
  • Treatment Outcome
  • Young Adult