Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience

Age (Dordr). 2015 Dec;37(6):109. doi: 10.1007/s11357-015-9849-y. Epub 2015 Oct 26.


The purpose of this study was to analyze the effects of a progressive resistance training (RT) program on C-reactive protein (CRP), blood glucose (GLU), and lipid profile in older women with differing levels of RT experience. Sixty-five older women (68.9 ± 6.1 years, 67.1 ± 13.1 kg) were separated according to RT experience: an advanced group composed by 35 participants who previously carried out 24 weeks of RT and a novice group composed by 30 participants without previous experience in RT (n = 30). Both groups performed a RT program comprised of eight exercises targeting all the major muscles. Training was carried out 3 days/week for 8 weeks. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), GLU, and CRP concentrations were determined pre- and post- intervention after 12 h fasting. A significant group by time interaction (P < 0.05) for the TC (novice = -1.9% vs. advanced = 1.0%), and CRP (novice = -22.9% vs. advanced = -54.5%) was observed. A main effect of time (P < 0.05) was identified for the GLU (novice = -2.6% vs. advanced = -6.6%), TG (novice = -12.9% vs. advanced = -5.7%), HDL-C (novice = +6.7% vs. advanced = +2.6%), and LDL-C (novice = -34.0% vs. advanced = -25.4%). These results suggest that RT improves the metabolic profile of older women and that training for a longer period of time seems to produce more pronounced reductions mainly on CRP.

Keywords: Aging; C-reactive protein; Lipoproteins; Strength training.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Blood Glucose / analysis*
  • C-Reactive Protein / metabolism*
  • Female
  • Humans
  • Lipids / blood*
  • Resistance Training*
  • Time Factors


  • Biomarkers
  • Blood Glucose
  • Lipids
  • C-Reactive Protein