Challenges in the Pharmacological Management of Nursing Home Residents with Overactive Bladder or Urinary Incontinence

J Am Geriatr Soc. 2015 Nov;63(11):2298-307. doi: 10.1111/jgs.13713. Epub 2015 Oct 27.

Abstract

Objectives: To determine the proportion of nursing home (NH) residents (NHR) with overactive bladder (OAB) or urinary incontinence (UI) with potential pharmacodynamic contraindications to antimuscarinic treatment because of concomitant anticholinergic medications or acetylcholinesterase inhibitors (AChEIs) and nonpharmacological limitations to antimuscarinic treatment.

Design: Cross-sectional retrospective analysis.

Setting: U.S. skilled nursing facilities.

Participants: Nursing home residents with a diagnosis of OAB or UI.

Measurements: Linked and deidentified pharmacy claims and Minimum Data Set (MDS) 3.0 records (October 1, 2010 to September 30, 2012).

Results: Of NHRs, 71.3% received at least one anticholinergic medication. Medications that can cause or worsen UI were used commonly. AChEIs and antimuscarinic treatment were prescribed concurrently in 24% of NHRs with OAB or UI. NHRs with OAB or UI were more likely to have concurrent moderate to severe cognitive impairment (MSCI) (70.1%) than those without (29.9%) (P < .001). NHRs with or without OAB or UI and with MSCI were more likely to be treated with an anticholinergic medication than those without MSCI (P = .001). When NHRs with MSCI, severe mobility impairment (SMI), and anticholinergic medication and AChEI use were excluded, only a small proportion of NHRs were potential candidates for antimuscarinic treatment (6.6% with OAB or UI, 6.2% with UI).

Conclusions: This study advances understanding of the challenges in prescribing antimuscarinic treatment safely and appropriately in elderly NHRs with a high prevalence of drug interactions, underlying MSCI, and SMI.

Keywords: nursing home; overactive bladder; urinary incontinence.

MeSH terms

  • Aged
  • Cholinergic Antagonists / administration & dosage*
  • Cholinesterase Inhibitors / administration & dosage
  • Cholinesterase Inhibitors / adverse effects
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Muscarinic Antagonists / administration & dosage*
  • Muscarinic Antagonists / adverse effects
  • Nursing Homes*
  • Retrospective Studies
  • Urinary Bladder, Overactive* / epidemiology
  • Urinary Incontinence* / epidemiology

Substances

  • Cholinergic Antagonists
  • Cholinesterase Inhibitors
  • Muscarinic Antagonists