Unresectable Middle Mediastinal Biphasic Pulmonary Blastoma

Anticancer Res. 2015 Nov;35(11):6325-7.


We report a case of a young male who presented with an unresectable, centrally-located classic biphasic pulmonary blastoma (CBPB) involving his bilateral mainstem bronchi and esophagus and a synchronous right testicular seminoma. CBPB is a rare and aggressive tumor that most commonly presents as a solitary mass in the periphery of the lung. Surgical resection is the preferred treatment for CBPB, as chemotherapy and radiation have demonstrated limited effectiveness. In the current case, four cycles of cisplatin, ifosfamide, and etoposide with concurrent radiotherapy resulted in a favorable response at three months. Currently he optimal treatment for unresectable pulmonary blastomas remains undefined.

Keywords: Lung pathology; mediastinum.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cisplatin / administration & dosage
  • Esophageal Neoplasms / drug therapy*
  • Esophageal Neoplasms / pathology
  • Etoposide / administration & dosage
  • Humans
  • Ifosfamide / administration & dosage
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / pathology
  • Male
  • Mediastinal Neoplasms / drug therapy*
  • Mediastinal Neoplasms / pathology
  • Neoplasm Staging
  • Neoplasms, Multiple Primary / drug therapy*
  • Neoplasms, Multiple Primary / pathology
  • Prognosis
  • Pulmonary Blastoma / drug therapy*
  • Pulmonary Blastoma / pathology
  • Testicular Neoplasms / drug therapy*
  • Testicular Neoplasms / pathology


  • Etoposide
  • Cisplatin
  • Ifosfamide