MT1-MMP: Endosomal delivery drives breast cancer metastasis

J Cell Biol. 2015 Oct 26;211(2):215-7. doi: 10.1083/jcb.201510009.


The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • ADP-Ribosylation Factors / metabolism*
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Female
  • Humans
  • Matrix Metalloproteinase 14 / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Triple Negative Breast Neoplasms / pathology*


  • Adaptor Proteins, Signal Transducing
  • Nerve Tissue Proteins
  • Matrix Metalloproteinase 14
  • ADP-Ribosylation Factors