The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

Food Funct. 2016 Jan;7(1):434-44. doi: 10.1039/c5fo01012h.


Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions <1 kDa obtained from PP and Alcalase®-Flavourzyme® hydrolysate (AF) at a dose of 15 mg kg(-1) of animal weight. PF > 10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33% for PF > 10 kDa from AF and 31.72% for PF > 10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Platelets / drug effects
  • Cells, Cultured
  • Cholesterol / chemistry
  • Diabetes Mellitus, Experimental
  • Dose-Response Relationship, Drug
  • Female
  • Fibrinolytic Agents / chemistry
  • Fibrinolytic Agents / pharmacology*
  • Humans
  • Hypercholesterolemia / drug therapy
  • Hyperlipidemias / drug therapy
  • Micelles
  • Mucuna / chemistry*
  • Platelet Aggregation / drug effects
  • Protein Hydrolysates / chemistry
  • Protein Hydrolysates / pharmacology*
  • Random Allocation
  • Rats
  • Rats, Wistar


  • Fibrinolytic Agents
  • Micelles
  • Protein Hydrolysates
  • Cholesterol