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. 2015 Dec:104:270-5.
doi: 10.1016/j.steroids.2015.10.013. Epub 2015 Oct 31.

Govanoside A, a new steroidal saponin from rhizomes of Trillium govanianum

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Govanoside A, a new steroidal saponin from rhizomes of Trillium govanianum

Shafiq-ur-Rahman et al. Steroids. 2015 Dec.

Abstract

A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trillium and all compounds (1-4) in T. govanianum are reported herein for the first time. Furthermore, compounds 1 &2 exhibited good to moderate activities against Aspergillus niger ATCC 16888, Aspergillus flavus ATCC 9643, Candida albicans ATCC 18804, and Candida glabrata ATCC 90030. This is a significant finding keeping in view the limited antifungal drugs for aspergillosis and candidiasis.

Keywords: Antifungal; Govanoside A; Spirostane glycosides; Trilliaceae; Trillium govanianum.

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