Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse

Cell Immunol. Nov-Dec 2015;298(1-2):88-95. doi: 10.1016/j.cellimm.2015.09.010. Epub 2015 Sep 28.

Abstract

Curcumin has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In the present study, the effect of curcumin on allergic responses in ovalbumin (OVA)-induced allergic rhinitis mouse was investigated. We explored the effect of curcumin on the release of allergic inflammatory mediators, such as histamine, OVA-specific IgE, and inflammatory cytokines. Also, we found that curcumin improved rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and decreased the serum levels of histamine, OVA-specific IgE and TNF-α in OVA-induced allergic rhinitis mice. In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-α, IL-1β, IL-6 and IL-8. Moreover, curcumin significantly inhibited PMA-induced p-ERK, p-p38, p-JNK, p-Iκ-Bα and NF-κB. These findings suggest that curcumin has an anti-allergic effect through modulating mast cell-mediated allergic responses in allergic rhinitis, at least partly by inhibiting MAPK/NF-κB pathway.

Keywords: Allergic rhinitis; Anti-inflammatory; Curcumin; Ovalbumin.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Curcumin / pharmacology*
  • Female
  • Histamine / blood
  • Histamine Release / drug effects*
  • Humans
  • I-kappa B Proteins / biosynthesis
  • Immunoglobulin E / blood
  • Interleukin-1beta / metabolism
  • Interleukin-6 / metabolism
  • Interleukin-8 / metabolism
  • Mast Cells / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • Mitogen-Activated Protein Kinases / biosynthesis
  • Myocardium / immunology
  • NF-KappaB Inhibitor alpha
  • Nasal Mucosa / immunology
  • Ovalbumin
  • Oxidative Stress / drug effects
  • Rhinitis, Allergic / chemically induced
  • Rhinitis, Allergic / drug therapy*
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Anti-Inflammatory Agents
  • I-kappa B Proteins
  • IL1B protein, mouse
  • Interleukin-1beta
  • Interleukin-6
  • Interleukin-8
  • NFKBIA protein, human
  • Nfkbia protein, mouse
  • Tumor Necrosis Factor-alpha
  • NF-KappaB Inhibitor alpha
  • Immunoglobulin E
  • Histamine
  • Ovalbumin
  • Mitogen-Activated Protein Kinases
  • Curcumin