Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder

C A Montojo; E Congdon; L Hwang; M Jalbrzikowski; L Kushan; T K Vesagas; R K Jonas; J Ventura; R M Bilder; C E Bearden

doi:10.1016/j.nicl.2015.08.006

Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder

Neuroimage Clin. 2015 Aug 20:9:310-21. doi: 10.1016/j.nicl.2015.08.006. eCollection 2015.

Authors

C A Montojo¹, E Congdon¹, L Hwang¹, M Jalbrzikowski¹, L Kushan¹, T K Vesagas¹, R K Jonas¹, J Ventura¹, R M Bilder¹, C E Bearden¹

Affiliation

¹ University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

Abstract

•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Adult
Analysis of Variance
Attention Deficit Disorder with Hyperactivity / complications*
Attention Deficit Disorder with Hyperactivity / pathology
Brain / blood supply
Brain / pathology*
Brain Mapping*
DiGeorge Syndrome / complications*
Female
Follow-Up Studies
Humans
Image Processing, Computer-Assisted
Impulsive Behavior / physiology*
Inhibition, Psychological*
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Oxygen / blood
Psychiatric Status Rating Scales
Statistics as Topic
Young Adult

Substances

Oxygen

Abstract

Publication types

MeSH terms

Substances

Grants and funding