Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance

J Clin Microbiol. 2016 Jan;54(1):185-9. doi: 10.1128/JCM.02227-15. Epub 2015 Oct 28.


In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteriological Techniques / methods*
  • Female
  • Humans
  • Male
  • Microscopy / methods*
  • Middle Aged
  • Sensitivity and Specificity
  • Time Factors
  • Tuberculosis, Lymph Node / diagnosis*
  • Tuberculosis, Multidrug-Resistant / diagnosis*
  • Young Adult