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Review
. 2015;15(11):1307-19.
doi: 10.1586/14737175.2015.1103183. Epub 2015 Oct 29.

Effect of Cocaine Dependence on Brain Connections: Clinical Implications

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Free PMC article
Review

Effect of Cocaine Dependence on Brain Connections: Clinical Implications

Liangsuo Ma et al. Expert Rev Neurother. .
Free PMC article

Abstract

Cocaine dependence (CD) is associated with several cognitive deficits. Accumulating evidence, based on human and animal studies, has led to models for interpreting the neural basis of cognitive functions as interactions between functionally related brain regions. In this review, we focus on magnetic resonance imaging (MRI) studies using brain connectivity techniques as related to CD. The majority of these brain connectivity studies indicated that cocaine use is associated with altered brain connectivity between different structures, including cortical-striatal regions and default mode network. In cocaine users some of the altered brain connectivity measures are associated with behavioral performance, history of drug use, and treatment outcome. The implications of these brain connectivity findings to the treatment of CD and the pros and cons of the major brain connectivity techniques are discussed. Finally potential future directions in cocaine use disorder research using brain connectivity techniques are briefly described.

Keywords: Brain connectivity; cocaine use disorder; effective connectivity; functional connectivity; magnetic resonance imaging.

Figures

Figure 1
Figure 1
Schematic diagram illustrating structural connectivity (fiber pathways, top), functional connectivity (correlations, middle), and effective connectivity (causal relationship, bottom) between two brain regions (R1 and R2).

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