Bupropion-SR plus naltrexone-SR for the treatment of mild-to-moderate obesity

Khawla F Ali; Alpana P Shukla; Louis J Aronne

doi:10.1586/17512433.2016.1100072

Bupropion-SR plus naltrexone-SR for the treatment of mild-to-moderate obesity

Expert Rev Clin Pharmacol. 2016;9(1):27-34. doi: 10.1586/17512433.2016.1100072. Epub 2015 Oct 29.

Authors

Khawla F Ali¹, Alpana P Shukla¹, Louis J Aronne¹

Affiliation

¹ a Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism , Weill Cornell Medical College , New York , NY , USA.

PMID: 26512740
DOI: 10.1586/17512433.2016.1100072

Abstract

Naltrexone-bupropion is a recently approved drug combination for chronic weight management. In this article, we discuss the rationale for its use as a combination followed by a comprehensive review of safety and efficacy data from major preclinical, phase II and III clinical trials.

Keywords: Naltrexone; bupropion; obesity; type 2 diabetes; weight loss.

Publication types

Review

MeSH terms

Animals
Anti-Obesity Agents / administration & dosage
Anti-Obesity Agents / adverse effects
Anti-Obesity Agents / therapeutic use*
Bupropion / administration & dosage
Bupropion / adverse effects
Bupropion / therapeutic use*
Delayed-Action Preparations
Drug Approval
Drug Combinations
Humans
Naltrexone / administration & dosage
Naltrexone / adverse effects
Naltrexone / therapeutic use*
Obesity / drug therapy*

Substances

Anti-Obesity Agents
Delayed-Action Preparations
Drug Combinations
bupropion hydrochloride, naltrexone hydrochoride drug combination
Bupropion
Naltrexone