Magnesium as a predictor of acute stent thrombosis in patients with ST-segment elevation myocardial infarction who underwent primary angioplasty

Coron Artery Dis. 2016 Jan;27(1):47-51. doi: 10.1097/MCA.0000000000000318.


Background: Although magnesium (Mg) has been proposed as a useful biomarker for predicting atherothrombosis, the association between Mg and acute stent thrombosis (ST) after primary percutaneous coronary intervention (p-PCI) for ST-segment elevation myocardial infarction (STEMI) has not yet been defined.

Objectives: We aimed to examine whether admission Mg levels predicted the development of acute ST after p-PCI in STEMI patients.

Methods and results: A total of 2633 patients with STEMI who underwent p-PCI were retrospectively analyzed. Acute ST was defined as thrombosis that occurred in the first (0-1) days following primary coronary stenting, and patients who had undergone p-PCI were divided into two groups: ST group and no-ST group. The cut-off value for Mg obtained by the receiver-operating characteristic curve analysis was less than 1.91 mg/dl for the prediction of acute ST (area under the curve was 0.761; 95% confidence interval, 0.706-0.816; P<0.001; sensitivity, 70%; specificity, 69%). Serum Mg levels were significantly lower in the ST group compared with the no-ST group (median 1.80 mg/dl, interquartile range 1.70-2.00 mg/l vs. median 2.10 mg/dl, interquartile range 1.90-2.20 mg/dl, P<0.001). After multivariable adjustment for clinical, laboratory, and angiographic variables, Mg remained a strong independent predictor for acute ST (odds ratio 5.802, 95% confidence interval, 3.069-10.967; P<0.001).

Conclusion: Serum Mg level is associated independently with the risk of acute ST in patients with STEMI who undergo p-PCI.

MeSH terms

  • Acute Disease
  • Angioplasty, Balloon, Coronary / adverse effects*
  • Biomarkers / blood
  • Coronary Angiography
  • Coronary Thrombosis / blood*
  • Coronary Thrombosis / epidemiology
  • Coronary Thrombosis / etiology
  • Electrocardiography*
  • Female
  • Follow-Up Studies
  • Graft Occlusion, Vascular / blood*
  • Graft Occlusion, Vascular / epidemiology
  • Graft Occlusion, Vascular / etiology
  • Humans
  • Incidence
  • Magnesium / blood*
  • Male
  • Middle Aged
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / surgery*
  • Prognosis
  • Retrospective Studies
  • Stents / adverse effects*
  • Survival Rate / trends
  • Time Factors
  • Turkey / epidemiology


  • Biomarkers
  • Magnesium