Update on Multistate Outbreak of Fungal Infections Associated with Contaminated Methylprednisolone Injections, 2012-2014

MMWR Morb Mortal Wkly Rep. 2015 Oct 30;64(42):1200-1. doi: 10.15585/mmwr.mm6442a4.

Abstract

During September 2012, CDC, in collaboration with state and local health departments and the Food and Drug Administration (FDA), investigated a multistate outbreak of fungal meningitis and other infections caused by injections of contaminated methylprednisolone acetate solution (MPA). After this unprecedented outbreak, scientists in the CDC Mycotic Diseases Branch, along with infectious diseases specialists who cared for patients from the outbreak, clinical experts, and public health officials from affected states, have continued to monitor the recovery of affected patients. A long-term follow-up study involving these patients was initiated and is being conducted by the Mycoses Study Group Education and Research Consortium (MSGERC). This update summarizes subsequent information about the current state of the outbreak.

MeSH terms

  • Disease Outbreaks*
  • Drug Contamination*
  • Humans
  • Injections, Spinal
  • Meningitis, Fungal / epidemiology*
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / adverse effects*
  • United States / epidemiology

Substances

  • Methylprednisolone