Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Filters applied. Clear all
. 2016 Feb;30(2):519-24.
doi: 10.1096/fj.15-279554. Epub 2015 Oct 29.

Studying Both Sexes: A Guiding Principle for Biomedicine

Free PMC article

Studying Both Sexes: A Guiding Principle for Biomedicine

Janine Austin Clayton. FASEB J. .
Free PMC article


In May 2014, the U.S. National Institutes of Health (NIH) announced that it will ensure that investigators account for sex as a biological variable (SABV) in NIH-funded preclinical research as part of the agency's rigor and transparency initiative. Herein, I describe in more detail the rationale behind the SABV policy component and provide additional detail about policy goals. In short, studying both sexes is a guiding principle in biomedical research that will expand knowledge toward turning discovery into health. NIH expects that considering SABV in preclinical research will help to build a knowledge base that better informs the design of clinical research and trials in humans. Integrating the practice of studying both sexes in preclinical research will, over time, expand our currently incomplete knowledge base that plays a critical role in informing the development of sex- and gender-appropriate medical care for women and men.

Keywords: NIH; SABV; gender; inclusion; sex-based biology.


Figure 1.
Figure 1.
Studying both sexes across the biomedical research continuum.

Similar articles

See all similar articles

Cited by 52 articles

See all "Cited by" articles

LinkOut - more resources