TRIM-NHL proteins in development and disease

Semin Cell Dev Biol. 2015 Dec;47-48:52-9. doi: 10.1016/j.semcdb.2015.10.017. Epub 2015 Oct 26.


TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for therapeutic intervention. The purpose of this review is to provide a systematic and comprehensive summary on the most studied TRIM-NHL proteins, highlighting examples where connections were established between structural features, molecular functions and biological outcomes.

Keywords: Bardet-Biedl syndrome; Brat; LIN-41; Limb girdle muscular dystrophy 2H; Mei-P26; NHL; Sarcotubular myopathy; TRIM; TRIM32; TRIM71.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / classification
  • Carrier Proteins / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Morphogenesis / genetics*
  • Mutation
  • Nuclear Proteins / classification
  • Nuclear Proteins / genetics*
  • Phylogeny
  • Transcription Factors / classification
  • Transcription Factors / genetics*
  • Tripartite Motif Proteins
  • Ubiquitin-Protein Ligases / classification
  • Ubiquitin-Protein Ligases / genetics*


  • Carrier Proteins
  • Narf protein, human
  • Nuclear Proteins
  • TRIM3 protein, human
  • Transcription Factors
  • Tripartite Motif Proteins
  • TRIM32 protein, human
  • TRIM71 protein, human
  • Ubiquitin-Protein Ligases