The reduced soluble fibrinogen-like protein 2 and regulatory T cells in acute coronary syndrome

Exp Biol Med (Maywood). 2016 Feb;241(4):421-5. doi: 10.1177/1535370215612138. Epub 2015 Oct 28.


Soluble fibrinogen-like protein 2, sfgl2, is the new effector of CD4(+)CD25(+)FOXP3(+) regulatory T cell (Treg) and exerts immunosuppressive activity. We design this study to investigate the possible role of sfgl2 in atherosclerosis. A total of 58 acute coronary syndrome (ACS) patients, together with 22 stable angina (SA) patients and 31 normal coronary artery (NCA) people were enrolled in our study. Serum level of sfgl2 and plasma level of Treg were respectively measured. In line with the change of Treg, serum level of sfgl2 in ACS (8.70 ng/mL) was significantly decreased (P = 0.003), compared with that in SA (11.86 ng/mL) and NCA (17.55 ng/mL). Both sfgl2 and Treg level were obviously decreased in ACS; Sfgl2 may play a protective role in atherosclerosis.

Keywords: Soluble fibrinogen-like protein 2; atherosclerosis; regulatory T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Coronary Syndrome / pathology*
  • Biomarkers / blood
  • CD4 Antigens / analysis
  • Female
  • Fibrinogen / analysis*
  • Forkhead Transcription Factors / analysis
  • Humans
  • Immune Tolerance*
  • Immunophenotyping
  • Interleukin-2 Receptor alpha Subunit / analysis
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Prospective Studies
  • T-Lymphocytes, Regulatory / chemistry
  • T-Lymphocytes, Regulatory / immunology*


  • Biomarkers
  • CD4 Antigens
  • FGL2 protein, human
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • IL2RA protein, human
  • Interleukin-2 Receptor alpha Subunit
  • Fibrinogen