The treatment of spontaneous intracerebral hemorrhage. A prospective randomized trial of surgical and conservative treatment

J Neurosurg. 1989 May;70(5):755-8. doi: 10.3171/jns.1989.70.5.0755.


In a prospective study, 52 patients with a spontaneous supratentorial intracerebral hematoma (ICH) were randomly assigned to receive emergency surgery or conservative treatment within 48 hours after the bleed. Patients with a decreased level of consciousness and/or a severe neurological deficit were admitted to the study. The overall mortality rate at 6 months was 42%: 10 (38%) of the 26 patients in the conservative group and 12 (46%) of the 26 in the surgical group. Six (20%) of the 30 survivors at 6 months were able to conduct their activities of daily living independently: five (31%) of the 16 patients in the conservative group and one (7%) of the 14 in the operative group. These differences are not statistically significant. The mortality rate of semicomatose or stuporous patients (Glasgow Coma Scale score 7 to 10) was statistically significantly lower in the surgical group (none of the four patients) than in the conservative group (four of five patients) (p less than 0.05); however, all surviving patients in this subgroup were severely disabled. The study suggests that surgical treatment of this category of patients with ICH does not offer any definite advantage over conservative treatment. In semicomatose or stuporous patients, surgery may improve the length of survival, but the quality of life remains poor.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cerebral Hemorrhage / mortality
  • Cerebral Hemorrhage / surgery
  • Cerebral Hemorrhage / therapy*
  • Clinical Trials as Topic
  • Coma / etiology
  • Coma / physiopathology
  • Consciousness
  • Humans
  • Intracranial Pressure
  • Middle Aged
  • Nervous System Diseases / etiology
  • Prospective Studies
  • Random Allocation