Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation

PLoS One. 2015 Oct 30;10(10):e0141068. doi: 10.1371/journal.pone.0141068. eCollection 2015.

Abstract

In this study, we considered a continuous model of platelet thrombus growth in an arteriole. A special model describing the adhesion of platelets in terms of their concentration was derived. The applications of the derived model are not restricted to only describing arterial platelet thrombus formation; the model can also be applied to other similar adhesion processes. The model reproduces an auto-wave solution in the one-dimensional case; in the two-dimensional case, in which the surrounding flow is taken into account, the typical torch-like thrombus is reproduced. The thrombus shape and the growth velocity are determined by the model parameters. We demonstrate that the model captures the main properties of the thrombus growth behavior and provides us a better understanding of which mechanisms are important in the mechanical nature of the arterial thrombus growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Algorithms
  • Arterioles / pathology*
  • Blood Platelets / physiology
  • Models, Cardiovascular
  • Platelet Aggregation*
  • Thrombosis / pathology*

Grant support

This study was supported by the Russian Science Foundation grant 14-14-00195. The funder HemaCore LLC provided support in the form of salaries for authors Fazoil I. Ataullakhanov and Mikhail A. Panteleev, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the “author contributions” section.