Oncosuppressive functions of tribbles pseudokinase 3

Biochem Soc Trans. 2015 Oct;43(5):1122-6. doi: 10.1042/BST20150124.

Abstract

Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases. In this article, we summarize several observation obtained by our laboratories supporting that TRIB3 plays a crucial role in the anti-cancer activity of cannabinoids (a novel family of potential anti-cancer agents derived from marijuana) and that TRIB3 genetic inactivation enhances cancer generation and progression.

Keywords: animal models of cancer; autophagy; cannabinoids; endoplasmic reticulum (ER) stress; tribbles pseudokinases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis / genetics
  • Apoptosis / physiology
  • Autophagy / genetics
  • Autophagy / physiology
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Endocannabinoids / metabolism
  • Humans
  • Models, Biological
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Protein Binding
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / physiology*

Substances

  • Cell Cycle Proteins
  • Endocannabinoids
  • Repressor Proteins
  • TRIB3 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt