Crosstalk between stem cell and cell cycle machineries

Curr Opin Cell Biol. 2015 Dec:37:68-74. doi: 10.1016/ Epub 2015 Nov 11.


Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle*
  • Cell Differentiation / physiology
  • Cellular Reprogramming
  • Embryonic Stem Cells / cytology*
  • Humans
  • Pluripotent Stem Cells / cytology*