A histamine-independent itch pathway is required for allergic ocular itch

Cheng-Chiu Huang; Yu Shin Kim; William P Olson; Fengxian Li; Changxiong Guo; Wenqin Luo; Andrew J W Huang; Qin Liu

doi:10.1016/j.jaci.2015.08.047

A histamine-independent itch pathway is required for allergic ocular itch

J Allergy Clin Immunol. 2016 Apr;137(4):1267-1270.e6. doi: 10.1016/j.jaci.2015.08.047. Epub 2015 Oct 28.

Authors

Cheng-Chiu Huang¹, Yu Shin Kim², William P Olson³, Fengxian Li⁴, Changxiong Guo¹, Wenqin Luo³, Andrew J W Huang⁵, Qin Liu⁶

Affiliations

¹ Department of Anesthesiology and the Center for the Study of Itch, Washington University School of Medicine, St Louis, Mo.
² Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Md.
³ Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pa.
⁴ Department of Anesthesiology and the Center for the Study of Itch, Washington University School of Medicine, St Louis, Mo; Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
⁵ Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Mo.
⁶ Department of Anesthesiology and the Center for the Study of Itch, Washington University School of Medicine, St Louis, Mo; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Mo. Electronic address: liuqi@anest.wustl.edu.

Abstract

Non-histaminergic TRPA1 neural pathway is required for the development of allergic ocular itch. Pharmacological inhibition of TRPA1 channel can lead to novel therapeutic strategies to treat ocular itch in severe allergic conjunctivitis.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Animals
Biomarkers / metabolism
Conjunctivitis, Allergic / complications
Conjunctivitis, Allergic / immunology*
Histamine / metabolism*
Mice
Mice, Knockout
Pruritus / immunology*
TRPA1 Cation Channel
TRPV Cation Channels / deficiency
TRPV Cation Channels / immunology*
Transient Receptor Potential Channels / deficiency
Transient Receptor Potential Channels / immunology*

Substances

Biomarkers
TRPA1 Cation Channel
TRPV Cation Channels
TRPV1 protein, mouse
Transient Receptor Potential Channels
Trpa1 protein, mouse
Histamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding