Effects of intravenous cocaine are partially attenuated by haloperidol

Psychiatry Res. 1989 Feb;27(2):117-25. doi: 10.1016/0165-1781(89)90127-3.


We examined the effect of the dopaminergic blocking agent, haloperidol, on the subjective and physiologic response to cocaine in cocaine-using volunteers. Five subjects received cocaine (40 mg) or placebo administered intravenously 20 min following pretreatment with haloperidol (8 mg) or placebo intramuscularly in a randomized double-blind study design. Haloperidol pretreatment attenuated cocaine-induced increases in systolic and diastolic blood pressure but not heart rate. Pretreatment with haloperidol reduced subject ratings of pleasant sensations but had no effect on drug "rush." Haloperidol (8 mg) has a small and limited effect on the subjective response to cocaine when given 20 min before cocaine.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Arousal / drug effects*
  • Blood Pressure / drug effects
  • Brain / drug effects
  • Clinical Trials as Topic
  • Cocaine / antagonists & inhibitors*
  • Cocaine / pharmacology
  • Double-Blind Method
  • Euphoria / drug effects*
  • Haloperidol / pharmacology*
  • Heart Rate / drug effects
  • Humans
  • Infusions, Intravenous
  • Injections, Intramuscular
  • Receptors, Dopamine / drug effects


  • Receptors, Dopamine
  • Cocaine
  • Haloperidol