Isoforms, Structures, and Functions of Versatile Spectraplakin MACF1

BMB Rep. 2016 Jan;49(1):37-44. doi: 10.5483/BMBRep.2016.49.1.185.


Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / chemistry
  • Actins / metabolism
  • Animals
  • Cell Movement
  • Embryo, Mammalian / metabolism
  • Humans
  • Microfilament Proteins / chemistry
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Protein Binding
  • Protein Isoforms / chemistry
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Protein Structure, Tertiary
  • Signal Transduction


  • Actins
  • MACF1 protein, human
  • Microfilament Proteins
  • Protein Isoforms