CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model

T Kocher; D Asslaber; N Zaborsky; S Flenady; U Denk; P Reinthaler; M Ablinger; R Geisberger; J W Bauer; M Seiffert; T N Hartmann; R Greil; A Egle; J Piñón Hofbauer

doi:10.1038/leu.2015.307

CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model

Leukemia. 2016 Jun;30(6):1409-13. doi: 10.1038/leu.2015.307. Epub 2015 Nov 2.

Authors

T Kocher^{1

2}, D Asslaber^{1

3}, N Zaborsky^{1

3}, S Flenady^{1

3}, U Denk^{1

3}, P Reinthaler^{1

3}, M Ablinger¹, R Geisberger^{1

3}, J W Bauer², M Seiffert⁴, T N Hartmann^{1

3}, R Greil^{1

3}, A Egle^{1

3}, J Piñón Hofbauer^{1

2}

Affiliations

¹ Laboratory for Immunological and Molecular Cancer Research, Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases, Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.
² EB House Austria, Research Program for the Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
³ Salzburg Cancer Research Institute, Salzburg, Austria.
⁴ Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD4-Positive T-Lymphocytes / immunology*
Disease Models, Animal*
Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
Mice
Mice, Transgenic
Proto-Oncogene Proteins / genetics*

Substances

Proto-Oncogene Proteins
Tcl1 protein, mouse

Publication types

MeSH terms

Substances

Grants and funding