Personalized management of cirrhosis by non-invasive tests of liver fibrosis

Clin Mol Hepatol. 2015 Sep;21(3):200-11. doi: 10.3350/cmh.2015.21.3.200. Epub 2015 Sep 30.


Owing to the high prevalence of various chronic liver diseases, cirrhosis is one of the leading causes of morbidity and mortality worldwide. In recent years, the development of non-invasive tests of fibrosis allows accurate diagnosis of cirrhosis and reduces the need for liver biopsy. In this review, we discuss the application of these non-invasive tests beyond the diagnosis of cirrhosis. In particular, their role in the selection of patients for hepatocellular carcinoma surveillance and varices screening is highlighted.

Keywords: FibroScan; FibroTest; Hepatocellular carcinoma; Transient elastography; Varices.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood
  • Carcinoma, Hepatocellular / diagnosis
  • Elasticity Imaging Techniques*
  • Endoscopy, Digestive System
  • Humans
  • Hypertension, Portal / complications
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / diagnosis*
  • Liver Neoplasms / diagnosis
  • Risk Factors


  • Biomarkers