Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;41:50-52.
doi: 10.1016/j.ijid.2015.10.022. Epub 2015 Oct 30.

Use of String Test and Stool Specimens to Diagnose Pulmonary Tuberculosis

Affiliations
Free PMC article

Use of String Test and Stool Specimens to Diagnose Pulmonary Tuberculosis

Andrew R DiNardo et al. Int J Infect Dis. .
Free PMC article

Abstract

Background: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10-85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum.

Methods: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied.

Results: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB.

Conclusion: The string test and stool provide diagnostic specimens that warrant further investigation.

Keywords: Stool; String test; Tuberculosis; Xpert MTB/RIF.

Similar articles

See all similar articles

Cited by 5 articles

References

    1. Steingart KR, Ng V, Henry M, Hopewell PC, Ramsay A, Cunningham J, et al. Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis. 2006;6:664–74. - PubMed
    1. Davis JL, Cattamanchi A, Cuevas LE, Hopewell PC, Steingart KR. Diagnostic accuracy of same-day microscopy versus standard microscopy for pulmonary tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13:147–54. - PMC - PubMed
    1. Steingart KR, Sohn H, Schiller I, Kloda LA, Boehme CC, Pai M, et al. Xpert(R) MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2013;1:CD009593. - PMC - PubMed
    1. Helb D, Jones M, Story E, Boehme C, Wallace E, Ho K, et al. Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology. J Clin Microbiol. 2010;48:229–37. - PMC - PubMed
    1. Detjen AK, DiNardo AR, Leyden J, Steingart KR, Menzies D, Schiller I, Dendukuri N, Mandalakas AM. Systematic review and meta-analysis: Xpert MTB/RIF for the diagnosis of pulmonary tuberculosis, peripheral lymph node TB and TB meningitis in children. WHO Expert Group Meeting on the Use of Xpert MTB/RIF in TB Control in Low and Middle-Income Settings.. WHO Expert Meeting; Veyrier-du-Lac. May 20-21, 2013.
Feedback