Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

Nat Neurosci. 2015 Dec;18(12):1722-4. doi: 10.1038/nn.4159. Epub 2015 Nov 2.


Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult Stem Cells / metabolism*
  • Animals
  • Cell Differentiation / physiology
  • Cell Lineage / genetics*
  • Hippocampus / cytology*
  • Hippocampus / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurofibromin 1 / deficiency*
  • Neurofibromin 1 / genetics*
  • Oligodendroglia / metabolism


  • Neurofibromin 1