Self-disseminating vaccines for emerging infectious diseases

Expert Rev Vaccines. 2016;15(1):31-9. doi: 10.1586/14760584.2016.1106942. Epub 2015 Nov 2.


Modern human activity fueled by economic development is profoundly altering our relationship with microorganisms. This altered interaction with microbes is believed to be the major driving force behind the increased rate of emerging infectious diseases from animals. The spate of recent infectious disease outbreaks, including Ebola virus disease and Middle East respiratory syndrome, emphasize the need for development of new innovative tools to manage these emerging diseases. Disseminating vaccines are one such novel approach to potentially interrupt animal to human (zoonotic) transmission of these pathogens.

Keywords: CMV; Disseminating; Ebola; cytomegalovirus; emerging infectious disease; epidemic; transmission; vaccine; wildlife; zoonosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Communicable Diseases, Emerging / epidemiology*
  • Communicable Diseases, Emerging / prevention & control*
  • Communicable Diseases, Emerging / transmission
  • Disease Transmission, Infectious / prevention & control*
  • Humans
  • Immunization / methods*
  • Vaccines / administration & dosage
  • Vaccines / immunology*
  • Vaccines / isolation & purification
  • Zoonoses / epidemiology*
  • Zoonoses / prevention & control*
  • Zoonoses / transmission


  • Vaccines

Grants and funding

MA Jarvis and AA Murphy declare conflicts of interest: patents EP1766096B1, EP2497831B1 and application EP2772265A3 (MA Jarvis); and UK applications No. 1508136.7, No. 1514005.6 and No. 1514034.6 (MA Jarvis and AA Murphy). The authors would like to acknowledge support by the School of Biomedical and Healthcare Sciences, Plymouth University (MA Jarvis and AA Murphy), The Marie Skłodowska-Curie Programme (MA Jarvis) and The Institute for Immunology and Infectious Diseases, Murdoch University (AJ Redwood). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.