Modulation of C-reactive protein and plasma omega-6 fatty acid levels by phospholipase A2 gene polymorphisms following a 6-week supplementation with fish oil

Prostaglandins Leukot Essent Fatty Acids. 2015 Dec;102-103:37-45. doi: 10.1016/j.plefa.2015.10.002. Epub 2015 Oct 22.


This clinical trial investigated the impact of a six-week supplementation with fish oil and single nucleotide polymorphisms (SNPs) in PLA2G4A and PLA2G6 genes on total omega-6 fatty acid (n-6 FA) levels in plasma phospholipids (PL) and plasma C-reactive protein (CRP) levels in 191 subjects. Interaction effects between SNPs and supplementation modulated total n-6 FAs and CRP levels in both men and women. Associations between SNPs and total n-6 FA levels and between SNPs and CRP levels were identified in men, independently of supplementation. Supplementation decreased total n-6 FAs without affecting plasma CRP levels. Changes in CRP levels correlated positively with changes in total n-6 FAs in men (r=0.25 p=0.01), but not in women. In conclusion, total n-6 FA levels in plasma PL and plasma CRP levels are modulated by SNPs within PLA2G4A and PLA2G6 genes alone or in combination with fish oil supplementation.

Keywords: C-reactive protein; Gene-diet interaction; Inflammation; Omega-3 fatty acid; Omega-6 fatty acid; Phospholipase A2.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / metabolism
  • Body Mass Index
  • C-Reactive Protein / analysis*
  • Dietary Supplements*
  • Fatty Acids, Omega-6 / administration & dosage
  • Fatty Acids, Omega-6 / analysis
  • Fatty Acids, Omega-6 / antagonists & inhibitors
  • Fatty Acids, Omega-6 / blood*
  • Female
  • Fish Oils / administration & dosage*
  • Fish Oils / metabolism
  • Genetic Association Studies
  • Group IV Phospholipases A2 / genetics*
  • Group IV Phospholipases A2 / metabolism
  • Group VI Phospholipases A2 / genetics*
  • Group VI Phospholipases A2 / metabolism
  • Humans
  • Male
  • Middle Aged
  • Nutrigenomics / methods
  • Overweight / blood
  • Overweight / genetics
  • Overweight / metabolism
  • Phospholipids / blood
  • Phospholipids / chemistry
  • Polymorphism, Single Nucleotide*
  • Quebec
  • Sex Characteristics
  • Young Adult


  • Anti-Inflammatory Agents, Non-Steroidal
  • Fatty Acids, Omega-6
  • Fish Oils
  • Phospholipids
  • C-Reactive Protein
  • Group IV Phospholipases A2
  • Group VI Phospholipases A2
  • PLA2G4A protein, human
  • PLA2G6 protein, human