Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis

Physiology (Bethesda). 2015 Nov;30(6):438-48. doi: 10.1152/physiol.00019.2015.


Plasma membrane repair is a conserved cellular response mediating active resealing of membrane disruptions to maintain homeostasis and prevent cell death and progression of multiple diseases. Cell membrane repair repurposes mechanisms from various cellular functions, including vesicle trafficking, exocytosis, and endocytosis, to mend the broken membrane. Recent studies increased our understanding of membrane repair by establishing the molecular machinery contributing to membrane resealing. Here, we review some of the key proteins linked to cell membrane repair.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • Cell Membrane / pathology
  • Homeostasis
  • Humans
  • Membrane Proteins / metabolism*
  • Regeneration*
  • Signal Transduction


  • Membrane Proteins