Effect of α7n-Acetylcholine Receptor Activation and Antibodies to TNF-α on Mortality of Mice and Concentration of Proinflammatory Cytokines During Early Stage of Sepsis

Bull Exp Biol Med. 2015 Oct;159(6):740-2. doi: 10.1007/s10517-015-3063-x. Epub 2015 Nov 3.

Abstract

Experiments on random-bred albino mice showed that activation α7n-acetylcholine receptors with anabasine (0.5 LD50) and the use of antibodies to TNF-α (1 mg/kg) 2 h before sepsis modeling significantly reduces mortality of mice from experimental sepsis (intraperitoneal injection of E. coli) due to a decrease in the blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. After combined administration of anti-TNF-α antibodies and anabasine, an additive effect was observed.

Keywords: antibodies to TNF-α; cholinergic anti-inflammatory pathway; proinflammatory cytokines; sepsis; α7n-acetylcholine receptors.

MeSH terms

  • Anabasine / pharmacology*
  • Animals
  • Antibodies / pharmacology*
  • Cytokines / blood*
  • Disease Progression
  • Female
  • Inflammation Mediators / blood*
  • Male
  • Mice
  • Sepsis / blood
  • Sepsis / mortality*
  • Sepsis / pathology
  • Time Factors
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / immunology*
  • alpha7 Nicotinic Acetylcholine Receptor / agonists*

Substances

  • Antibodies
  • Cytokines
  • Inflammation Mediators
  • Tumor Necrosis Factor-alpha
  • alpha7 Nicotinic Acetylcholine Receptor
  • Anabasine