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Comment
. 2015 Dec;23(12):744-746.
doi: 10.1016/j.tim.2015.10.006. Epub 2015 Oct 29.

Programming Bacteriophages by Swapping Their Specificity Determinants

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Programming Bacteriophages by Swapping Their Specificity Determinants

Moran G Goren et al. Trends Microbiol. .

Abstract

Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

Keywords: bacteriophage adsorption; host-range expansion; host-recognition ligand; shaping bacterial microbiome.

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