Neurodegenerative disease: C9orf72 repeats compromise nucleocytoplasmic transport

Nat Rev Neurol. 2015 Dec;11(12):670-2. doi: 10.1038/nrneurol.2015.219. Epub 2015 Nov 3.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Active Transport, Cell Nucleus / genetics*
  • Amyotrophic Lateral Sclerosis / metabolism*
  • Animals
  • Cell Nucleus / metabolism*
  • DNA Repeat Expansion / genetics*
  • DNA Repeat Expansion / physiology*
  • Dipeptides / metabolism*
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / metabolism*
  • Female
  • Frontotemporal Dementia / metabolism*
  • Humans
  • Male
  • Open Reading Frames / genetics*
  • Proteins / genetics*
  • Proteins / metabolism*
  • RNA Transport / genetics*

Substances

  • Dipeptides
  • Proteins