Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure

Annu Rev Med. 2016;67:215-28. doi: 10.1146/annurev-med-011514-023043. Epub 2015 Nov 2.

Abstract

An estimated 35 million people worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive. Recent case reports have suggested that curing HIV infection is possible, renewing excitement about research efforts. We describe those cases and discuss their relevance to the global HIV epidemic. We also review ongoing cure strategies that are transitioning from the lab to the clinic, and the assays and clinical assessments that can be used to evaluate cure interventions.

Keywords: HIV-1; early treatment; genome editing; persistence; shock and kill; vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS Vaccines
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use*
  • CD4-Positive T-Lymphocytes / virology
  • Disease Eradication*
  • Genetic Therapy
  • HIV Infections / drug therapy
  • HIV Infections / prevention & control*
  • HIV Infections / therapy
  • HIV* / immunology
  • HIV* / isolation & purification
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Secondary Prevention
  • Virus Integration

Substances

  • AIDS Vaccines
  • Anti-HIV Agents