Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy

Neuro Oncol. 2016 Jun;18(6):779-89. doi: 10.1093/neuonc/nov269. Epub 2015 Nov 2.

Abstract

Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients. Overall incidence and mechanisms of epileptogenesis are reviewed. Factors to consider with the use of antiepileptic drugs (AEDs) including incidence during the disease trajectory and prophylaxis along with considerations in the selection of anticonvulsant use (ie, potential side effects, drug interactions, adverse effects, and impact on survival) are also reviewed. Finally, areas for future research and exploring the pathophysiology and use of AEDs in this population are also discussed.

Keywords: anticonvulsant; epilepsy; glioma; seizure.

Publication types

  • Review

MeSH terms

  • Anticonvulsants / administration & dosage
  • Anticonvulsants / therapeutic use*
  • Brain Neoplasms / drug therapy*
  • Drug Interactions
  • Epilepsy / drug therapy*
  • Glioma / drug therapy*
  • Humans
  • Treatment Outcome

Substances

  • Anticonvulsants