Chemical sporulation and germination: cytoprotective nanocoating of individual mammalian cells with a degradable tannic acid-FeIII complex

Nanoscale. 2015 Dec 7;7(45):18918-22. doi: 10.1039/c5nr05573c. Epub 2015 Nov 3.

Abstract

Individual mammalian cells were coated with cytoprotective and degradable films by cytocompatible processes maintaining the cell viability. Three types of mammalian cells (HeLa, NIH 3T3, and Jurkat cells) were coated with a metal-organic complex of tannic acid (TA) and ferric ion, and the TA-Fe(III) nanocoat effectively protected the coated mammalian cells against UV-C irradiation and a toxic compound. More importantly, the cell proliferation was controlled by programmed formation and degradation of the TA-Fe(III) nanocoat, mimicking the sporulation and germination processes found in nature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Proliferation* / drug effects
  • Cell Proliferation* / radiation effects
  • Ferric Compounds* / chemistry
  • Ferric Compounds* / pharmacokinetics
  • Ferric Compounds* / pharmacology
  • HeLa Cells
  • Humans
  • Jurkat Cells
  • Mice
  • NIH 3T3 Cells
  • Sunscreening Agents* / chemistry
  • Sunscreening Agents* / pharmacokinetics
  • Sunscreening Agents* / pharmacology
  • Tannins* / chemistry
  • Tannins* / pharmacokinetics
  • Tannins* / pharmacology
  • Ultraviolet Rays*

Substances

  • Ferric Compounds
  • Sunscreening Agents
  • Tannins