Surface polysaccharides from Acinetobacter baumannii: Structures and syntheses

Denis Giguère

doi:10.1016/j.carres.2015.10.001

Surface polysaccharides from Acinetobacter baumannii: Structures and syntheses

Carbohydr Res. 2015 Dec 11:418:29-43. doi: 10.1016/j.carres.2015.10.001. Epub 2015 Oct 22.

Author

Denis Giguère¹

Affiliation

¹ Département de Chimie, Université Laval, Québec City, Québec, Canada G1V 0A6. Electronic address: denis.giguere@chm.ulaval.ca.

PMID: 26531136
DOI: 10.1016/j.carres.2015.10.001

Abstract

The emergence of multidrug-resistance Acinetobacter baumannii requires novel approaches for prevention, treatment and diagnosis. The structures of surface polysaccharides from A. baumannii are valuable tools to understand pathogenesis, virulence and immunogenicity. The synthesis of bacterial mono- or polysaccharides may result in novel probes to become important therapeutic options in the fight against A. baumannii. This report exemplifies the relevance of glycochemistry for the development of new antibiotics.

Keywords: Acinetobacter baumannii; Capsular polysaccharides; Lipopolysaccharides; Polysaccharide synthesis; Surface polysaccharides.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acinetobacter baumannii / chemistry*
Molecular Conformation
Polysaccharides, Bacterial / chemical synthesis*
Polysaccharides, Bacterial / chemistry*
Surface Properties

Substances

Polysaccharides, Bacterial