Screening for breast cancer with Breast-CT in a ProHTA simulation

J Comp Eff Res. 2015 Nov;4(6):553-67. doi: 10.2217/cer.15.42. Epub 2015 Nov 4.


Aims: The potential of dedicated Breast-CT is evaluated by simulating its impact onto the performance of the German breast cancer screening program. Attendance rates, cancer detection and economic implications are quantified.

Methods: Based on a prospective health technology assessment approach, we simulated screening in different scenarios.

Results: In the simulation, attendance rates increase from 54 to up to 72% due to reduced pain. Breast cancers will be detected earlier while nodal positives and distant recurrences decrease. Assuming no additional cost, cost savings of up to €55 million in one screening period are computed.

Conclusion: The simulation indicates that earlier cancer detection, fewer unnecessary biopsies and less pain are potential benefits of Breast-CT resulting in cost savings and higher attendance.

Keywords: breast cancer; computed tomography; health economics; health technology assessment; mammography screening; simulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / epidemiology
  • Early Detection of Cancer / instrumentation*
  • Female
  • Germany / epidemiology
  • Humans
  • Middle Aged
  • Prospective Studies
  • Sensitivity and Specificity
  • Technology Assessment, Biomedical*
  • Tomography, X-Ray Computed / standards*