Seasons of Risk: Anticipated Behavior on Vacation and Interest in Episodic Antiretroviral Pre-exposure Prophylaxis (PrEP) Among a Large National Sample of U.S. Men Who have Sex with Men (MSM)

AIDS Behav. 2016 Jul;20(7):1400-7. doi: 10.1007/s10461-015-1238-0.


The current analysis evaluates interest in and acceptability of daily PrEP during short episodes of anticipated increased risk (i.e. Epi-PrEP). In 2013, U.S. members of an internet-based MSM sexual networking site were invited to complete a survey about HIV prevention practices in the context of vacationing. 7305 MSM responded to the survey. Of respondents who had vacationed in the past year, 25.6 % reported condomless anal sex (CAS) with new male sex partners while vacationing. Most (92.6 %) respondents agreed that having to use PrEP every day was a barrier to PrEP use and 74.3 % indicated they would take PrEP if they knew it would be helpful for short periods of anticipated increased risk. MSM who reported increased CAS while on vacation in the past year were more likely to indicate that they would take PrEP if it were helpful when used for short periods than respondents who did not (aOR = 2.02, 95 % CI 1.59-2.56, p < 0.001). Studies designed to evaluate uptake, adherence, and protective benefit of short PrEP courses are warranted.

Keywords: Epi-PrEP; Episodic PrEP; HIV; MSM; PrEP.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • HIV Infections / prevention & control*
  • HIV Infections / psychology
  • Homosexuality, Male / psychology
  • Homosexuality, Male / statistics & numerical data*
  • Humans
  • Internet
  • Male
  • Middle Aged
  • Patient Acceptance of Health Care / statistics & numerical data
  • Pre-Exposure Prophylaxis / methods*
  • Risk-Taking
  • Safe Sex
  • Seasons
  • Sexual Behavior / statistics & numerical data
  • Sexual Partners*
  • Surveys and Questionnaires
  • United States
  • Unsafe Sex / psychology
  • Young Adult


  • Anti-HIV Agents