Intra-abdominal abscesses arise from complications of surgery and disease. Computed tomography (CT) facilitates abscess drainage procedures while reducing the risks and costs associated with surgery. These procedures require collaboration to ensure positive patient outcomes. To perform their role in CT-guided intra-abdominal abscess drainage, radiologic technologists must understand patient care, instrumentation, imaging techniques, and underlying disease processes specific to the anatomical site. Once these considerations are grasped, CT technologists can help radiologists and administrators to determine cost-effective instrumentation and quality control specific to the patient and institution.