A loopy view of telomere evolution

Front Genet. 2015 Oct 20:6:321. doi: 10.3389/fgene.2015.00321. eCollection 2015.


About a decade ago, I proposed that t-loops, the lariat structures adopted by many eukaryotic telomeres, could explain how the transition from circular to linear chromosomes was successfully negotiated by early eukaryotes. Here I reconsider this loopy hypothesis in the context of the idea that eukaryotes evolved through a period of genome invasion by Group II introns.

Keywords: DNA damage; Group II intron; eukaryote; replication; telomerase; telomere.