The absolute oral bioavailability of selected drugs

Int J Clin Pharmacol Ther Toxicol. 1989 Apr;27(4):179-211.


Oral bioavailability is best defined as the rate and extent to which an active drug substance is absorbed and becomes available to the general circulation. This concept is discussed, along with several popular methods for determining absolute oral bioavailability. The absolute oral bioavailability of numerous drugs is reviewed and interspecies comparisons are made. In general, absolute oral bioavailability does not correlate well between species, though relative comparisons might be made.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Availability*
  • Humans
  • Pharmacokinetics*