Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation

Biosci Biotechnol Biochem. 2016;80(3):547-53. doi: 10.1080/09168451.2015.1107463. Epub 2015 Nov 5.


Ferulic acid (FA) has been reported to exhibit protective effects against amyloid-β (Aβ)-induced neurodegeneration in vitro and in vivo. Recently, we developed two water-soluble FA derivatives: 1-feruloyl glycerol and 1-feruloyl diglycerol. In this study, we examined the neuroprotective effects of these water-soluble FA derivatives on Aβ-induced neurodegeneration both in vitro and in vivo. FA and water-soluble FA derivatives inhibited Aβ aggregation and destabilized pre-aggregated Aβ to a similar extent. Furthermore, water-soluble FA derivatives, as well as FA, inhibited Aβ-induced neuronal cell death in cultured neuronal cells. In in vivo experiments, oral administration of water-soluble FA derivatives to mice improved Aβ-induced dysmnesia assessed by contextual fear conditioning test and protected hippocampal neurons against Aβ-induced neurotoxicity. This study provides useful evidence suggesting that water-soluble FA derivatives are expected to be effective neuroprotective agents.

Keywords: Alzheimer’s disease; amyloid-β; ferulic acid; neuroprotective agent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Peptides / physiology*
  • Animals
  • Cell Death / physiology*
  • Coumaric Acids / chemistry*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neurons / cytology*
  • Solubility
  • Water


  • Amyloid beta-Peptides
  • Coumaric Acids
  • Water
  • ferulic acid