Evaluation and clinical significance of appendicular skeletal assessment by radiographic photodensitometry

J Manipulative Physiol Ther. 1989 Apr;12(2):113-9.


"Senile" or age-related bone loss affects cortical and trabecular bone and may be detected in the appendicular as well as the axial skeleton. This study presents radiographic photodensitometry as a precise and sensitive technique for evaluating appendicular skeletal status. Data from reproducibility studies indicate that the coefficient of variation for the technology is between 1.9% and 4.5% for the three bones analyzed. Evaluation of age-related changes in bone mass for over 800 subjects demonstrated a decline in mass vs. age after the fourth decade in women, with the slope of the decline being very similar to that seen in CT longitudinal studies. Applied serially to a patient over time, the technology identifies changes in bone mass and may be used to evaluate the response to intervention therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Absorptiometry, Photon*
  • Age Factors
  • Aged
  • Bone and Bones / analysis*
  • Bone and Bones / diagnostic imaging
  • Female
  • Humans
  • Menopause / physiology
  • Middle Aged
  • Osteoporosis / diagnosis*
  • Osteoporosis / diagnostic imaging
  • Radiographic Image Interpretation, Computer-Assisted